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Author Hwa Mi Kang, Tae Hoon Oh, Ji Young Seo, Tae Joo Joen, Dong Dae Seo, Won Chang Shin, Won Choong Choi and Jung Yeon Kim1
Place of duty Departments of Internal Medicine and Pathology1, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Title Clinical Factors Predicting for Neoplastic Transformation of Gastric Hyperplastic Polyps
Publicationinfo The Korean Journal of Gastroenterology 2011 Oct; 058(04): 184-189.
Key_word Stomach; Hyperplastic; Polyps; Neoplastic; Transformation
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Abstract Background/Aims: Hyperplastic polyps (HPs) are the most common cause of all benign epithelial gastric polyps, constituting 30 to 93%. Although gastric HPs are usually considered as benign lesions compared with adenoma, neoplastic transformation has been known to occur rarely. We aimed to identify the clinical factors of gastric HPs predicting for neoplastic transformation. Methods: Between January 2002 to August 2010, a total of 274 gastric HPs, which had been removed by endoscopic polypectomy or surgical resection from 210 patients, were analyzed retrospectively.Results: Neoplastic transformation was found in 15 cases (5.5%) of 274 HPs including 10 cases of low grade dysplasia (3.7%), 2 cases of high grade dysplasia (0.7%) and 3 cases of adenocarcinoma (1.1%). Neoplastic transformations were significantly associated with >1 cm in size (n=10 [66.7%] vs. n=91 [35.1%], p=0.024), with pedunculated shape (n=9 [60.0%] vs. n=62 [23.9%], p=0.002), with previous history of gastrectomy (n=3 [20.0%] vs. n=3 [1.2%], p=0.002) and with synchronous neoplastic lesions occurring elsewhere in the gastric mucosa (n=5 [33.3%] vs. n=31 [12.0%], p=0.021). However, no significant difference was found between HPs with and without neoplastic transformation in terms of age, sex, number of polyps detected per patient, location, macroscopic appearance such as erosion, hyperemia.Conclusions: Neoplastic transformation of gastric HPs had significant relationships with >1 cm in size, pedunculated shape, postgastectomy state, and synchronous neoplastic lesion. Therefore, endoscopic polypectomy should be considered in these HPs to avoid the risk of missing HPs with neoplastic potential. (Korean J Gastroenterol 2011;58:184-189)
저 자 강화미, 오태훈, 서지영, 전태주, 서동대, 신원창, 최원충, 김정연1
소 속 인제대학교 의과대학 상계백병원 내과학교실, 병리학교실1
제 목 위 증식폴립의 종양전환에 관한 임상적 예측인자
출판정보 Korean J Gastroenterol 2011 Oct; 058(04): 184-189.
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