대한소화기학회로고
 
 
 
Author Ji Hyun Lee, Gyoo Moon1, Hyeok Jin Kwon, Woo Jin Jung, Pyoung Ju Seo, Tai Yoon Baec, Ju Hyeong Lee2 and Hyun Shig Kim
Place of duty Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, Seoul, Department of Gastroenterology, Hanam Song Do Colorectal Hospital1, Hanam, Songdo Biocell Research Institute2, Seoul, Korea
Title Effect of a Probiotic Preparation (VSL#3) in Patients with Mild to Moderate Ulcerative Colitis
Publicationinfo The Korean Journal of Gastroenterology 2012 Aug; 060(02): 94-101.
Key_word Probiotics; Ulcerative colitis; Cytokines
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Abstract Background/Aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC.Methods: Twenty-four eligible patients with mild to moderate UC received open-label VSL#3 4 sachets daily in 2 divided doses for 8 weeks. The disease activity pre- and post-VSL#3 therapy was assessed by ulcerative colitis disease activity score and colonic tissue cytokine profiling done at baseline and at week 8.Results: Twenty-four patients (mean age, 43.7 years; range, 20-70 years; male/female, 15/9) were enrolled and 2 patients did not have the final endoscopic assessment. A total of 22 patients were analyzed. Intent to treat analysis demonstrated remission in 45.8% of subjects (n=11); partial response in 20.8% (n=5); no change or worse in 25.0% (n=6) of subjects. The mean ulcerative colitis disease activity index (UCDAI) scores decreased from 7.09±1.81 to 1.45±1.29 in patients with a remission (p<0.001). The mean endoscopic scores had also significantly decreased from 1.91±0.54 to 0.63±0.50 in patients with a remission (p<0.001). The concentrations of colonic cytokines did not change significantly during treatment in patients with a remission.Conclusions: Our study demonstrated that VSL#3 is effective in achieving clinical responses and remissions in patients with mild-to moderately active UC, further supporting the potential role in UC therapy. (Korean J Gastroenterol 2012;60:94-101)
제 목 경도 및 중등도 활동성 궤양성 대장염 환자에서의 VSL#3의 효능
출판정보 Korean J Gastroenterol 2012 Aug; 060(02): 94-101.
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